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Adrenal Complex 120 capsules Designs For Health

$49.00

Adrenal Complex is a glandular-based product designed to support overall adrenal function. It is fortied with N-acetyl tyrosine, vitamin C and a comprehensive spectrum of B vitamins. It is ideal for those under chronic stress due to its ability to balance cortisol and replenish catecholamines (dopamine, norepinephrine, and epinephrine). Adrenal complex supports healthy connective tissue and cartilage formation.

This is a professional line item. If you are unsure of the suitability of this supplement, please Book with our Naturopathic Doctor.

SKU: ADC120-CN
NPN: 80050214

UPC Code: 879452001435

SKU: 879452001435 Category:

Adrenal Complex is a glandular-based adrenal product offering comprehensive support for overall adrenal and hypothalamic-pituitary-adrenal (HPA) axis function. The adrenal glands are mainly responsible for secreting cortisol and catecholamines (epinephrine and norepinephrine), the hormones involved in mediating stress responses. In addition to causing the depletion of a host of micronutrients, stress can alter levels of cortisol and catecholamines in a detrimental manner.
CORTISOL
Maintaining ideal levels of cortisol, referred to as the “stress hormone,” is critical to health. The adrenals secrete this hormone during the body’s “fight or flight” response to stress. Small increases of cortisol are often welcomed, such as those quick bursts of energy necessary in crisis situations for survival reasons, or in helping to maintain homeostasis in the body. However, higher than normal levels of cortisol for prolonged amounts of time, as seen with chronic stress, have been shown to have negative effects on the body. For example, cortisol increases serum blood glucose and insulin levels, inducing dysglycemia and laying the foundation for metabolic syndrome.
THE HPA AXIS
The HPA axis is an interdependent, tightly-linked neuroendocrine unit which makes up a major component of the body’s stress-response system. The hypothalamus and pituitary form the central part of the HPA axis, whose main function is to control reactions to stress, maintaining stress-related homeostasis. It is the combined system of neuroendocrine units (the nervous and endocrine systems as they function together) which regulate the adrenal gland’s hormonal activities. Chronic stress induced by physiological, psychological, and other environmental factors may impair optimal function of this interconnected neuroendocrine system. Dysregulation of the HPA axis is associated with a poor stress response, inappropriate production, release, and activity of critical hormones and catecholamines, and a myriad of physiological disturbances.
WHY INCLUDE GLANDULARS?
The inclusion of tissue-specific glandulars from both the adrenal cortex as well as the whole gland provides a variety of micronutrients to support adrenal health. In addition to being rich in an array of vitamins and minerals, these adrenal glandulars contain protein-like substances which may have specific messenger activity that help target the body’s adrenal tissues for optimal function.
With the ever-increasing concerns over the safety of glandular materials, we have gone to extreme lengths to obtain the purest and cleanest sources of glandulars on the market today. Our glandular materials are obtained only from certified BSE-free countries (Argentina) and are freeze-dried to prevent rancidity.
ADDITIONAL KEY INGREDIENTS
The amino acid n-acetyl-l-tyrosine, the most bioavailable form of tyrosine, is included as a critical building block of catecholamines (often depleted under chronic stress conditions). Research shows that supplementing with tyrosine may be useful for individuals exposed to chronic stress. For example, a review in 2015 provides evidence that in cognitively-demanding and/or short-lived stressful moments such as multitasking and sleep deprivation, tyrosine supplementation can effectively improve cognitive function and performance and reverse stress-induced catecholamine neurotransmitter depletion.

The inclusion of vitamin C is critical since it also plays an important role in cortisol levels. One particular study looked at the “adrenal-vitamin C axis” in certain mammalian species who do not synthesize vitamin C and found there is a strong inverse correlation between cortisol levels and vitamin C. Results revealed that after a physical or psychological stressor, supplementing with vitamin C was associated with a decreased cortisol response.
Another study indicated that supplementing with vitamin C and other antioxidants may reduce exercise-induced stress by decreasing HSPA1A and HSPB1 mRNA expression in white blood cells.

Also included in Adrenal Complex is the B vitamin family — thiamine HCl (B1), pantothenic acid (B5), pyridoxine-B6 (as P-5-P) and riboflavin-B2 (as R-5-P) — which play critical roles as enzyme cofactors in the balanced production of stress hormones. The B vitamin profile is a comprehensive spectrum of Bs, most provided in their pre-activated phosphorylated form for superior bioavailability. Vitamin B6 is a key nutrient involved in acceleration of the GABAergic system, a chemical compound responsible for reducing corticotropin-releasing hormone (CRH), which lowers adrenal output of cortisol.5 The same review indicates that those who supplement with 3000 mg of vitamin C per day had quicker cortisol recovery after acute stress, in addition to a decrease in cortisol level growth, reduction of muscle pain, and an increase in the processes involved in regeneration among athletes.
Similar patterns were discerned with high dose supplementation of vitamins B1, B2, and B3.5 Another study found multivitamin supplementation containing B vitamins for 16 weeks in healthy adults led to an overall increased cortisol awakening response, which indicates enhanced adaptive stress response.

It is important to note pantothenic acid’s role, as it helps the adrenal glands generate more cortisol when needed. In a study conducted on male rats, the adrenal cells in those given pantothenic acid exhibited higher basal levels of corticosterone than the control rats, demonstrating that pantothenic acid supplementation stimulates the ability of adrenal cells to secrete corticosterone.
A study conducted in 2015 addressed the impact of thiamine (vitamin B1) and exercise on brain-derived neurotrophic factor (BDNF) and acetylcholine (Ach) in the hippocampus of stressed animal models. The researchers found that 30 day B1 supplementation improved the ability to cope with chronic stress through BDNF and Ach modulation as well as enhancing motor activities and memory function.
All of the ingredients in Adrenal Complex are combined in order to synergistically promote proper homeostasis of serum cortisol, nurture healthy hypothalamic-pituitary function, aid in the production and replenishment of depleted catecholamines, support adrenal cortical health, and replete common nutritional deficiencies that can result from chronic stress. Taking Adrenal Complex during exposure to chronic stress may help reduce stress-related side effects.
SUGGESTED LABORATORY STUDIES
Abnormal salivary cortisol on the Adrenal Stress Indices and low catecholamine markers, such as VMA and HVA, found on Organic Acid Tests, may indicate the need for Adrenal Complex and/or Adrenotone™.
Medicinal Ingredients (per capsule):
Pantothenic acid (Calcium d-pantothenate) ……………………………………………………………………..125 mg
Cattle (Bos taurus) (Adrenal gland) …………………………………………………………………………………100 mg
PABA (para-Aminobenzoic acid)………………………………………………………………………………………50 mg
Vitamin C (Ascorbic acid)………………………………………………………………………………………………..50 mg
Cattle (Bos taurus) (Adrenal cortex)………………………………………………………………………………… 25 mg
N-Acetyl-L-tyrosine (N-Acetyltyrosine)…………………………………………………………………………… 25 mg
Vitamin B2 (Riboflavin)…………………………………………………………………………………………………. 2.5 mg
Vitamin B6 (Pyridoxal 5-phosphate) ………………………………………………………………………………. 2.5 mg
Thiamine (Thiamine hydrochloride)…………………………………………………………………………………1 mg

Non-Medicinal Ingredients: Microcrystalline cellulose, bovine gelatin (capsule), magnesium stearate (vegetable source.)

Recommended Dose: Adults: Take 2 capsules per day, or as directed by your health care practitioner.

Consider combining with Adrenotone™ for comprehensive adrenal support.
Use with caution with pregnant or lactating women, and with individuals on prescription medication, especially sulfonamide drugs. Hypersensitivity has been known to occur; in which case, discontinue use; May cause gastrointestinal discomfort including abdominal rumbling, soft stools or slight constipation.

 

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Brand

Designs For Health

About Designs for Health

Our Company Since 1989, Designs for Health has been the health care professional's trusted source for research-backed nutritional products of superior quality. By providing comprehensive support through our extensive product line, ongoing clinical education, and practice development programs, we are able to maximize the potential for successful health outcomes. Our wide array of added-value services not only set us apart, but indicate the depth of our commitment to you. Jonathan and Linda Lizotte, RD, CDN, founded Designs for Health in 1989 with a local team of nutritionists. Managing 22 Northeastern offices, the company's initial focus was to provide nutrition counseling services for the treatment of a variety of health conditions. The success of this endeavor grew, as did the demand for nutritional products to satisfy the specific treatment needs of the company's clinical nutritionists. Realizing that a genuine need existed for a line of nutritional supplements designed by health care professionals, for health care professionals, Designs for Health focused its efforts in this direction. Of utmost importance to the health professionals served by Designs for Health was ?? and still is ?? quality ingredients, efficacious doses, and company integrity. The formation of a Designs for Health branded supplement line led to mass requests from clinicians for further education and support. Advanced training courses were offered, dealing with nutritional approaches to chronic disease. To better serve its customers, Designs for Health responded in 1996 by directing its resources toward the establishment of 3 primary divisions: Professional Products, Research and Education, and Practice Development. With its roots in education, Designs for Health remains committed to providing the latest scientific nutrition research via innovative seminars and conferences. To this day, nutritionally-minded clinicians with ongoing clinical experiences shape the direction of the company. By holding itself to extremely high standards and delivering results, Designs for Health has established itself as one of the fastest growing manufacturers and distributors of nutritional supplements, selling exclusively to the health professionals market. Led by a talented and committed team of professionals whose ultimate goal is to help people lead healthier lives, Designs for Health delivers on its promise to provide the highest quality nutritional products available ?? and the dedicated relevant support needed to ensure optimal results.