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Bioclinic Berberine HCl

$44.99

This is a professional line item. If you are unsure of the suitability of this supplement, Book an appointment with one of our Naturopathic Doctors or consult with a  qualified healthcare practitioner.

Maintains Healthy Glucose Metabolism
500 mg
90 Vegetarian Capsules

SKU: 9231,
NPN: 80062118
UPC Code: 629022094561

Description

Benefits

  • Provides 500 mg berberine HCl per capsule, the dosing strength used in clinical trials for glucose and lipid control
  • Hypoglycemic effects via multiple mechanisms, including enhancement of insulin sensitivity
  • Favourable effects on blood lipids, including a reduction in triglycerides, and both total and LDL cholesterol 9
  • Activates Nrf-2, a key regulator of antioxidant gene transcription and prevention of glucose-induced neurotoxicity
  • Extracted from Berberis vulgaris (European barberry)
  • Suitable for vegetarians/vegans

Feature Summary

Traditionally used for gastrointestinal symptoms, berberine has emerged as a potent cardiometabolic aid with diverse benefits and mechanisms of action. It has hypoglycemic effects, via both an inhibition of alpha-glucosidase activity and an upregulation of insulin receptors in peripheral tissues, thereby improving insulin sensitivity.1,2 Furthermore, it activates Nrf2, a key regulator of cellular antioxidant defense, and attenuates glucose induced neurotoxicity, suggesting a therapeutic potential for diabetic neuropathy.3

In controlled trials it reduced HbA1c levels in diabetic participants with comparable efficacy to metformin. Among participants with the metabolic syndrome it has been shown to reduce waist circumference and body weight, blood pressure, triglycerides, and improve insulin resistance compared to placebo, with similar benefits in women with PCOS.4,5 Berberine targets multiple cardiometabolic risk factors, as it has been shown to also lower total and LDL cholesterol among diabetic participants in several controlled trials.6,7 Additionally, a clinical trial comparing standard therapy with or without berberine among patients receiving percutaneous coronary intervention showed improvements in multiple inflammatory markers, including C-reactive protein, IL-6, MMP-9, ICAM-1, and VCAM-1.8

Medicinal Ingredients

Each Capsule Contains:
Berberine (Hydrochloride) (Berberis vulgaris) (root) 500 mg

Non-Medicinal Ingredients

Vegetarian capsule (cellulose, purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica, stearic acid.

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.

Contraindications

Do not use if you are pregnant or breastfeeding.

Drug Interactions

Berberine has been shown to lower blood glucose levels, and may have an additive effect when combined with other hypoglycemic medications, such as metformin. Berberine has also been shown to increase levels of cylcosporin A, and combined use should be avoided.10 Berberine has demonstrated inhibitory activity on cytochrome enzymes CYP2D6, 3A4, and CYP2C9, and use of medications metabolized by these enzymes should be monitored.11

 

Brand

Brand

Bioclinic Naturals

At Bioclinic Naturals, we offer an exclusive health care practitioner line of evidence-based natural health products. Each formula is developed by the industry leading, outstanding scientists and health care practitioners on our Scientific Advisory Board to meet, and exceed, the needs of your patients. Every great product starts with the best ingredients. Our goal is to provide the best quality, tested raw materials. We have certified organic farmland in Canada’s Okanagan Valley, and whenever possible we grow our own plant-based ingredients. Any raw material we do not produce ourselves is subjected to the highest level of scrutiny to ensure the quality and purity. We are Canada’s leading nutraceutical manufacturer. We have state-of-the-art manufacturing facilities that include tabulating and softgel encapsulation. Our standards meet or surpasses the Canadian Good Manufacturing Practices (GMPs) established by the Natural and Non-Prescription Health Products Directorate (NNHPD) of the Canadian Federal Government, and Canadian Food Inspection Agency (CFIA) regulations. Our products also meet or exceed other international standards including the US Federal Drug Administration (FDA), the US Pharmacopeial Convention (USP), the Korean Ministry of Health and Welfare (MHW), and the Australian Therapeutic Goods Administration (TGA). Our commitment to quality is reflected in the our investment in expanding our in-house Quality Control, Quality Assurance, and Research & Development departments, allowing us to verify the purity, potency, and efficacy of each and every product. We have advanced analytical technology and equipment, including HPLC and Mass Spectrometry, and can test for over 400 contaminants down to the molecular level. We adhere strictly to good laboratory practices (GLP), and our products are ISURA certified. This third party certification tests for non-GMO, contaminants, and identity. Bioclinic Naturals’ focus is on clinical application for nutritional interventions and strategies for preventive medicine. Our unique formulas meet practitioners’ needs for both condition-specific challenges and overall health enhancement. Our continual commitment to product quality in every stage of production for every product ensures that our products have earned the trust of practitioners and their patients. We work closely with our Scientific Advisory Board to ensure that our products live up to their claims. Their scientific investigation focuses on the clinical application of our products, as well as nutritional interventions and strategies for preventive medicine. At Bioclinic Naturals, we don’t just say that we provide the most effective natural health products – we prove it. We have the science and clinical research to back up our products for quality, potency, and effectiveness.
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