Melatonin Bioclinic Naturals
Melatonin 3mg
Sleep is a vital part of health and many of us are not getting enough. The 2002 Canadian Community Health Survey found about 1 in 7 adults has difficulty falling asleep or staying asleep. Insomnia affects 1 in 3 seniors and is 40% more common in women. Changes in sleeping patterns are largely reflective of our circadian rhythms, which are guided by the pineal hormone, melatonin. Melatonin Bioclinic Naturals is known to decline as we age, which accounts for a number of the sleep changes we see throughout life. Additionally, jet lag and shift work can significantly alter circadian rhythms and thus melatonin secretion.1,2,3
In the face of insomnia, many people have tried prescription sleeping pills, but they can interfere with REM sleep, disrupt deeper stages of sleep and lead to confusion, sluggishness, anxiety and even drug dependency. Conversely, melatonin has shown clinical benefit for inducing sleep or adjusting sleep cycles,4 reducing sleep onset latency and improving perceived quality of sleep, without impairing daytime psychomotor performance.5,6 In fact, supplemental melatonin and bright light therapy are considered standard medical treatment for cases of jet lag, shift work, age-related insomnia, delayed sleep-phase disorder, advanced sleep-phase disorder, and non-24-hour sleep-wake disorder.7 Chronic sleep disturbance is a risk factor for premature aging, diabetes, obesity, cardiovascular disease and certain cancers,8 demonstrating just how important it is to maintain normal melatonin levels to enhance sleep quality.
Benefits
- Sublingual tablets provide consistent melatonin bioavailability – pharmacokinetic studies indicate that 30 to 60% of an oral dose of melatonin is metabolized via the liver9 and overall gastrointestinal absorption is variable10,11
- 3 mg strength is optimal for those who require basic sleep support or are trying melatonin for the first time
- Derived from non-animal sources
- Refreshing, natural peppermint flavour
Medicinal Ingredients
| Each Tablet Contains: | |
| Melatonin (vegetarian source) | 3 mg |
Non-Medicinal Ingredients
Lactose monohydrate, microcrystalline cellulose, natural peppermint flavour, croscarmellose sodium, vegetable grade magnesium stearate (lubricant).
Allergens:
Contains no artificial colours, preservatives, or sweeteners; no starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, salt, tree nuts, or GMOs. Suitable for vegetarians.
Recommended Use:
Recommended Adult Dose: Do not drive or use machinery for 5 hours after taking melatonin. Dissolve 1 tablet under the tongue at bedtime once per day or as directed by a health care practitioner. Consult a health care practitioner for use beyond 4 weeks.
Contraindications
Consult a health care practitioner prior to use if you have a hormonal disorder, diabetes, liver or kidney disease, cerebral palsy, seizure disorders, migraine, depression and/or hypertension, or if you are taking blood pressure or sedative/hypnotic medications. Do not use if you are taking immunosuppressive drugs and/or if you are pregnant or breastfeeding. Do not drive or use machinery for 5 hours after taking melatonin. If symptoms persist continuously for more than 4 weeks (chronic insomnia), consult your health care practitioner.12 Keep out of reach of children.
Drug Interactions
Melatonin can stimulate immune function and may reduce the efficacy of immunosuppressive drugs.13 Theoretically, concomitant use of melatonin with sedative/hypnotic or central nervous system depressants may be additive. However, benzodiazepines may also reduce endogenous melatonin levels.14 Melatonin can reduce the efficacy of blood pressure medication nifedipine GITS (Procardia XL).15 Case reports suggests melatonin may potentiate anticoagulant and antiplatelet medications, however, the mechanism and clinical significance are unknown.16 Additionally, melatonin may impair glucose utilization and increase insulin resistance in diabetic patients. However, the clinical significance of this effect on diabetics is unknown.17 Contraceptive drugs can increase endogenous melatonin levels. Theoretically, this may increase the effects and adverse effects of oral melatonin use.18 Fluvoxamine significantly inhibits the elimination of melatonin,19 which some researchers believe could be helpful in the treatment of refractive insomnia.20 However, this interaction may also cause excessive unwanted drowsiness and other adverse effects. 629022092857
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