small amounts by the human body and is abundantly found in various plant foods such as broccoli,
cabbage, kale, apples, oranges, and grapefruit. Research shows that d-glucaric acid derivatives such
as calcium d-glucarate help support the body’s defense against toxins and excess sex hormones,
making calcium d-glucarate a potential agent in aiding detoxification.
MECHANISM OF ACTION
In the GI tract, calcium d-glucarate is metabolized into three compounds, the most active being
D-glucaro-1,4-lactone. This metabolite increases detoxification by inhibiting β-glucuronidase, an
enzyme that can prevent proper and healthy excretion of potential toxins from the body. During liver detoxification some toxins and hormones such as estrogen, are cleared via glucuronidation – a process where glucuronic acid is attached to a toxin in order to create a less toxic conjugate
that can be readily eliminated by the body. In the case of liver detoxification, the substrates are most
often foreign xenobiotic substances such as drugs and pollutants, as well as endogenously produced
compounds like excess estrogens and androgens, mineralcorticoids, glucocorticoids, fatty acid
derivatives, retinoids, and bile acids. Theses toxins and hormones, bound to glucuronic acid, are now
ready to be safely eliminated.
• Supports detoxification of xenobiotics
• Supports healthy hormone metabolism and excretion
Recommended Dose: Adults: Take 2 capsules per day with meals, or as directed by your health care practitioner. Take a few hours before or after taking other medications or natural health products.
Actual product packaging and materials may contain more and different information than what is shown on our website.
We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product or Book with one of BodyCrafters Physicians / Naturopathic Doctors or a Certified Natural Product Advisor.