Excess homocysteine in the circulation can damage the lining of arterial walls, making them narrow and inelastic. Research suggests that a raised homocysteine level is an independent risk factor for
hardening of the arteries, coronary heart disease, stroke, peripheral vascular disease and other conditions associated with abnormal blood clotting. Elevated homocysteine is also linked with a number of other serious medical conditions including depression, osteoporosis,
Alzheimer’s disease, multiple sclerosis, rheumatoid arthritis, spontaneous abortion, placental abruption, neural tube defects (spina bifida, cleft palate, etc.), renal failure, and type II diabetes.
Supreme™ facilitate the efficient metabolism of homocysteine, and prevent toxic levels of homocysteine from accumulating. Homocysteine Supreme™ allows the homocysteine pathway (which
begins with methionine) to flow smoothly in any direction, producing its necessary and important end products, including the sulfurcontaining amino acids taurine and cysteine and the neurotransmitters
epinephrine, dopamine, and serotonin.
Homocysteine is produced by the demethylation of dietary methionine which comes from protein-containing foods. It is recycled back into methionine through a pathway that involves vitamin B12 in the form of methylcobalamin (which remethylates it) and folate. Homocysteine is simply an intermediate in a very important biochemical pathway. Plasma homocysteine can also travel another route which involves the passing of sulfur groups (transsulfuration). This is vitamin B6-dependent and results in the production of cysteine which can convert into glutathione, the most important
antioxidant in the body.
Any roadblock in this pathway can cause homocysteine to elevate. When we intricately study the biochemistry of the homocysteine pathway we can see that it involves a series of conversions that require enzymes. Several nutrients, especially B vitamins, are needed for these conversions to occur.13 Stress can deplete B vitamins, as can many medications.
The Comprehensive Metabolic Profile (CMP) test offered by Designs for Health can pinpoint B vitamin deficiencies. It is also important to test the body’s homocysteine levels. Performing both tests on women wishing to get pregnant could reduce the risk of neural tube defects and pregnancy complications. All patients with homocysteine levels above 7 are in need of intervention,12 with Homocysteine Supreme™ being an ideal recommendation. Patients with a family history of early heart attacks or depression are also prime candidates for such intervention.
Who should not take Homocysteine Supreme™?
Patients undergoing chemotherapy, radiation, or taking Methotrexate should not take high dose folate without consulting with their health care practitioner.
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