NIACIN CRT™ 60 Tablets Designs for Health


This is a professional line item. If you are unsure of the suitability of this supplement, please Book with our Naturopathic Doctor.

NIACIN helps the body to metabolize carbohydrates, fats and proteins.

Additional Information/Highlights: Niacin CRT™ is a unique wax-matrix tablet, which utilizes the latest Controlled Release Technology (CRT). This technology delivers niacin in a continuous, controlled rate over a 6-8 hour period, throughout the tablet’s transit time in the bowel. Flushing sometimes happens with time-release niacin, as there can be fairly large surges of niacin released intermittently. However, flushing is less likely with controlled release niacin.

NPN: 80045715

UPC Code: 879452002081

SKU: 879452002081 Category: Tag:

Niacin CRT™ offers beneficial doses of niacin (as nicotinic acid) in a unique wax-matrix tablet that utilizes the latest controlled-release technology (CRT) for optimal bioavailability. It is available in controlled release tablets formulated to deliver niacin in a continuous designed release pattern over a six to eight hour period, the transit time through the bowels. Niacin, also known as vitamin B3 or nicotinic acid (NA), is an essential cofactor in several metabolic pathways in the body due to its function as coenzymes NAD (nicotine-adenine dinucleotide) and NADP (nicotine-adenine dinucleotide phosphate) in hundreds of metabolic reactions including oxidation-reduction reactions, mitochondrial aerobic respiration, and cellular energy production. Similarly, niacin, in the form of NAD, is an essential cofactor for the enzymes in the folate/tetrahydrobiopterin and methionine cycles. Niacin receptors are distributed and expressed in immune cells, adipose tissue, and the brain, supporting niacin’s roles in modulating lipolysis in adipocytes and regulating the inflammatory cascade. There are two G-protein-couple membrane receptors that bind NA;2 the high-affinity niacin receptor 1 (NIACR1) is responsible for high-dosage skin flushing, and GRP109A and TRPV1 receptors are responsible for the anti-atherosclerotic effects of NA.3 Studies demonstrate doses >1 g/day exert anti-inflammatory effects via niacin receptor activity, enhance insulin sensitivity, reduce the size of adipocytes, exert anti-atherogenic effects on lipid markers, and increase niacin receptor expression in fat cells.1
In healthy subjects, 2 g extended-release niacin dosed just before a high-fat meal acutely suppressed postprandial triglyceridemia by 33% compared to placebo,4 and similarly, markedly decreased postprandial production of lipoprotein(a) and apolipoproteinB-100 concentrations in statin-treated type 2 diabetics due to niacin’s inhibitory activity on the rate-limiting enzyme that catalyzes the final reaction in triglyceride synthesis, and via upregulation of fatty acid oxidation in the liver.5 Niacin’s lipid-lowering capabilities were discovered in the 1950s in experimental studies when researchers reported nicotinic acid’s ability to lower serum cholesterol and inhibit lipid deposition in both healthy and hypercholesterolemic animals when administered in gram doses.6,7 A meta-analysis showed that high dose niacin supplementation (between 1-3 g per day) administered with or without cholesterol-lowering medication reduced cardiovascular disease (CVD) and coronary heart disease incidences associated with its beneficial effects on inflammatory biomarkers via modulation of NIACR1 receptors.1,8 A systematic review of the literature found that niacin treatment significantly increased serum HDL-cholesterol levels by 21.4% from baseline measures, and was associated with trends towards reduced risk of CVD mortality, heart attack, coronary death, and stroke; however, the results showed no differences in all-cause mortality rates compared to controls.9 In a pilot study of hypoalphalipoproteinemia patients with serum HDL-C levels ≤ 40 mg/dL, extended-release NA treatment significantly increased total HDL cholesterol and phospholipids, HDL2 levels, and HDL particle size, as well as HDL cholesterol efflux and uptake capacity.

Recommended Dose
Adults: Take one tablet per day with a meal, or as directed by your health care practitioner. Dosing recommendations are given for typical use based on an average 150 pound healthy adult. Health care practitioners are encouraged to use clinical judgement with case-specific dosing based on intended goals, subject body weight, medical history, and concomitant medication and supplement usage.

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Designs For Health

About Designs for Health

Since 1989, Designs for Health has stood as the go-to source for health professionals seeking top-tier, research-backed nutritional products. Their commitment is evident through an extensive product line, continuous clinical education, and programs aiding in practice development. Their diverse range of services not only sets them apart but showcases their unwavering dedication. Founded by Jonathan and Linda Lizotte, RD, CDN, with a team of local nutritionists, Designs for Health initially focused on nutrition counseling across 22 Northeastern offices. As the demand surged for specialized nutritional products, the company turned its attention to crafting supplements tailored by health care professionals for health care professionals. Their emphasis on quality ingredients, effective doses, and unwavering integrity remains paramount. The evolution into a branded supplement line sparked significant interest among clinicians, leading to comprehensive education and support initiatives, particularly addressing chronic diseases. In 1996, the company established three primary divisions: Professional Products, Research and Education, and Practice Development, to better serve its clientele. Rooted in education, Designs for Health continually provides the latest scientific nutritional research through pioneering seminars and conferences, shaped by nutritionally-focused clinicians with extensive clinical backgrounds. By upholding exceptionally high standards and delivering impactful results, Designs for Health has emerged as one of the fastest-growing manufacturers and distributors of nutritional supplements, exclusively catering to health professionals. Driven by a devoted team aspiring to enhance people's well-being, Designs for Health fulfills its commitment to offer the finest quality nutritional products and dedicated support for optimal results.
Trusted by health professionals since 1989, Designs for Health has been a reliable source for cutting-edge, research-backed nutritional products. Their extensive product line and commitment to ongoing education ensure optimal health outcomes. With a focus on quality, efficacy, and integrity, they stand as a leading choice for tailored supplements crafted by health experts, dedicated to enhancing wellness.
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