Sensitol™ is a unique formulation comprised of two naturally occurring isomers of inositol – myo-inositol (MI) and D-chiroinositol (DCI) – along with alpha lipoic acid, designed to modulate the metabolic pathways involved in insulin resistance. Insulin resistance (InsR) is a syndrome involving a dysregulation of insulin and glucose metabolism that has been implicated as a causative and/or aggravating factor in many pathological conditions and diseases such as:
• Polycystic Ovarian Syndrome (PCOS) • Metabolic Syndrome (MetS) and Obesity
• Type II Diabetes (T2D) • Gestational Diabetes
• Gout
• Various inflammatory conditions
• Brain degenerative conditionsGenetics seem to play a role in the risk of developing all these conditions, along with lifestyle and diet, while supplementation with specific nutrients or herbal extracts can help reduce this risk
Highlights
Inositol
Inositol occurs naturally as nine isomers in a variety of vegetable and animal foods as well as in the human body. Two of the isomers, myo-inositol (MI) and D-chiro-inositol (DCI), have been recognized to be the most predominant and have important functions in human physiology, such as mediating cell signaling from insulin and from sex and thyroid hormones. average adult consumes approximately 900mg/day of myo-inositol. However, it is not clear how much dietary inositol is actually absorbed.
Inositol Supplementation
Inositols are not considered essential nutrients since they can be synthesized in the body from glucose at the rate of 2-4g MI/day.
However, MI and DCI may be considered conditionally essential nutrients for conditions where dysglycemia and InsR play
critical roles, and for which dietary inositol intake and endogenous production are not adequate, such as MetS, gestational diabetes, T2D and PCOS. us, MI and DCI supplementation with InsR may help bring insulin signaling and glucose metabolism
closer to homeostasis.
Combining Alpha Lipoic Acid (ALA) with MI:
• ALA has been shown to increase insulin sensitivity by approximately 20-30%.46,47
• ALA is a cofactor for the pyruvate dehydrogenase (PDH) enzyme.46 Since DCI-IPG (DCI-inositol phosphoglycan) is also a
cofactor of the PDH enzyme, these two endogenous metabolites may act in synergy to boost PDH activity, which in turn
supports the conversion of glucose to energy.
MI and DCI Derivatives and Insulin Signaling
MI and DCI are components and precursors of intracellular signaling mediators of insulin action (see Figure 1). MI and DCI
derivatives include phosphoinositol phosphates (PIPs) and inositol phosphoglycans (IPGs): MI-IPG and DCI-IPG.
DCI-IPG contains a methylated form of DCI and galactosamine, while MI-IPG contains MI and glucosamine; both contain zinc
and manganese.
How to Take
• Take two capsules, two times per day, ideally 12 hours apart, or as directed by a health care practitioner.
• Best taken on an empty stomach, especially away from meals high in carbohydrates.21,22 Inositol absorption is also impaired by compounds in coffee.
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