Tricobalamin™ lozenges are formulated to support healthy levels of vitamin B12, providing a synergistic combination of the three bioavailable forms of this vitamin: methylcobalamin, hydroxycobalamin, and adenosylcobalamin. These three forms of B12 are naturally present in foods, and can be readily converted to the active intracellular forms of B12, such as methylcobalamin, adenosylcobalamin, glutathionylcobalamin, and potentially other physiologically active B12 forms.
THE LOZENGE ADVANTAGE
Tricobalamin™ uses a lozenge delivery system, allowing for two routes of absorption for B12: 1) directly through the oral mucosa, and 2) bound by haptocorrin (a binding protein secreted in saliva) and carried to the GI tract.
There are many conditions where a B12 deficiency acts as an etiological or aggravating factor. Many of these conditions have been shown to improve with adequate B12 supplementation (at doses around 0.5-1 mg). It is often necessary to optimize the status of many other synergistic nutrients in order to maintain health. Folate is one of the most important cofactors that helps optimize the benefits of B12 repletion. Other B vitamins, essential minerals, and fatty acids also work in conjunction with B12, and thus a multivitamin, multimineral, and/or fatty acid supplement should always be considered in a well-rounded treatment plan.
• Nervous system related impairments: brain and nerve function, myelin repair issues, such as during chemotherapy or any condition involving neurological autoimmunity. Many of these conditions may involve poor cognition, dementia, dizziness, postural hypotension, tinnitus, neuropathy, or hyporeflexia.
• Impaired healing of oral or GI mucosa: canker sores, various inflammatory conditions of the gut, or during treatment with NSAIDs or chemotherapy. Gastric mucosa damage causes B12 malabsorption, thus creating a vicious cycle of worsening B12 status and the health of all mucosal membranes.23
• Low white blood cells: which impairs immunity.
• Low platelet count: which impairs healing.
• Anemia, and/or macrocytic red blood cells: (high mean corpuscular volume), impaired circulation and oxygen supply.
• Elevated homocysteine: associated with increased risk of birth defects, cardiovascular disease and cognitive decline. It is also an indicator of systemically impaired capacity for methylation, which is involved in neurotransmitter synthesis and clearance, hormonal methylation and genetic expression through DNA methylation. Conditions that involve impairment of energy production and low oxygen supply to cells, such as generalized fatigue, anemia, heart failure, respiratory disease, and shortness of breath may also benefit.
• Poor sleep quality: B12 may be involved in normalization of circadian rhythm.105
• Impotence, incontinence
• Infertility or high risk of miscarriage or birth defects (5X higher risk for spina bifida) and poor cognitive and motor development of the fetus or infant, due to mother’s B12 deficiency during pregnancy and breastfeeding.
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