Aloe/200x Designs for Health

Aloe/200x contains certified organically grown aloe vera (Aloe barbadensis) in a concentrated form to ensure efficacious results. The number reflected in the product’s name refers to the fact that it takes 200 pounds of the aloe vera inner gel fillets to make one pound of this nourishing aloe extract.
The extract from the leaves of the succulent aloe vera plant has long been used as a natural topical first aid for burns, scrapes, and other skin irritations.1,2 Aloe not only cools and soothes damaged epithelial cells on the exterior of the body, but it may also soothe inflammation internally in the stomach and middle and lower GI tract. Aloe also possesses antioxidant and antibacterial properties, which may account for its immunosupportive effects. Research indicates that aloe may be a useful adjunct in helping combat gastrointestinal inflammation caused by high amounts of psychological stress, the use of NSAIDs, corticosteroids and/or alcohol.

HIGH QUALITY ALOE EXTRACT PREPARATION
Designs for Health’s aloe vera is prepared using a low-heat dehydration method with no filtering, which ensures that the long polysaccharide chains remain intact and that as much of the plant’s natural makeup is retained as possible. It is believed that the beneficial biological properties of aloe are a function of these polysaccharides contained in the extracted gel of the leaves.3,4 Specifically, the mannan, glucomannan, and acetylated mannan (acemannan) fractions are believed to be the primary components responsible for the thick, mucilage-like texture of raw aloe leaf gel that is so soothing to inflamed tissue. 5 These biological effects are preserved in the manufacturing of Aloe/200x™.
Testing via High Performance Liquid Chromatography (HPLC) confirms that the polysaccharide chains present in Aloe/200x™ range in size from 140,000 daltons to over 1,000,000 daltons, retaining the large mucopolysaccharides found in the fresh unprocessed leaf. According to research, the longer chains (over 800,000 daltons) possess an immune-modulating action within the body, with the longest aloe polysaccharides (greater than 1,000,000 daltons) proving to be the most effective for stimulating the immune system.

GASTROINTESTINAL PROTECTION
In a mouse model of ethanol-induced gastric lesions, freeze-dried aloe vera extract was shown to be protective against lesion development, both in quantity and severity. This effect is primarily due to aloe’s influence on mRNA expression of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS), two critical biomarkers for this type of gastric ulceration.6 Treatment with aloe resulted in nearly a 50 percent reduction in these markers, compared to controls. While nitric oxide is a known vasodilator, high levels are associated with gastric inflammation, ulceration, and runaway oxidative stress. A substance that attenuates the production of elevated amounts of nitric oxide, such as aloe, may have beneficial effects on protecting and healing the gastric mucosa.6
In another rat model of gastric lesions, aloe vera was shown to reduce markers of inflammation and facilitate healing. In the group treated with aloe, gastric inflammatory markers were reduced, and epithelial cell proliferation and repair were enhanced, compared to the non-treated group.7 Aloe vera contributed to reduced levels of TNF-α, and elevated levels of IL-10, an anti-inflammatory signaling molecule.

According to this study, IL-10 contributed to reduced inflammation through feedback inhibition on
TNF-α production.
In other animal models of gastric ulcers, aloe vera has demonstrated gastro-protective effects in addition to mildly inhibiting gastric acid secretion as a natural H2 receptor antagonist, which may be helpful in healing active ulcerations without the side-effects of more powerful pharmaceutical acid-reducing drugs.

Recommended Dose
Adults: Take 1 capsule per day, or as directed by your health care practitioner.

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