Chromium Synergy Designs for health
Chromium Synergy™ is a synergistic blend of nutrients formulated to support normal blood sugar regulation and insulin sensitivity. Each one-capsule serving provides a clinically relevant 300 mcg of chromium nicotinate along with vanadium, taurine, zinc and other nutrients that play a role in glucoregulation. The blend is delivered in a base of cinnamon powder, as cinnamon is recognized for its traditional use to support normal blood sugar balance. All minerals in Chromium Synergy™ are provided as amino acid chelates which are better absorbed and retained in the body than non-chelated mineral salts.
The foundational ingredient in this product is chromium nicotinate. Chromium is well-regarded for aiding in glucoregulation, primarily by way of enhancing insulin sensitivity.1,2 The effects of chromium on fasting blood glucose and hemoglobin A1c are so dramatic that this mineral has been called “an inexpensive, convenient adjunct for the treatment of diabetes.”3 Changes in diet and lifestyle are essential for improving blood glucose and insulin dynamics particularly in those with type 2 diabetes or metabolic syndrome, but chromium supplementation has been shown to be beneficial for reducing HbA1c, glucose, insulin, and cholesterol among type 2 diabetics even in the absence of these changes. Glucocorticoid drugs are known to induce hyperglycemia and have even led to “steroid-induced diabetes.” Chromium supplementation has been shown to reverse this effect, with affected patients showing reductions in fasting blood glucose from 250 mg/dl to less than 150 mg/dl.5 Patients receiving chromium supplements (600 mcg/d) were able to reduce their hypoglycemic drugs by 50%. The estimated safe and adequate daily dietary intake for chromium for adults is 50-200 mcg.6 However, modern diets typically provide less than 60% of the bare minimum7, and this does not account for very high-carbohydrate diets potentially increasing the need for chromium as evidenced by a diet high in simple sugars increasing chromium excretion by nearly 300%.
The trace mineral vanadium has beneficial effects on blood glucose control.9 No overt vanadium deficiency syndrome has been identified in humans, but based on its biochemical properties researchers believe vanadium is likely an essential trace nutrient. Vanadium supplementation has been shown to improve glucoregulation and insulin resistance in human and animal models of both type 1 and type 2 diabetes. The main mechanism of action of vanadium seems to be that it enhances and potentiates the action of insulin. It improves insulin sensitivity in liver and muscle cells while inhibiting some of the enzymes involved in gluconeogenesis, such as phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (shown in animal models and in vitro).16,17 Vanadium also activates several key elements that regulate insulin signaling, such as tyrosine phosphorylation of the insulin receptor, and phosphatidylinositol 3-kinase (PI3K). In a related mechanism, vanadium inhibits protein tyrosine phosphatases, which are thought to downregulate insulin signaling.18
In a rat model of insulin-dependent diabetes, treatment with vanadium (as vanadyl sulfate) reduced the insulin requirement by 75%.19 Animal studies suggest that vanadium is not effective in the absence of insulin, so rather than being an insulin mimetic, vanadium is believed to make available insulin more effective through its influence on signaling and
receptor activity.
Adults: Take 1 capsule of Chromium Synergy™ per day with a meal, a few hours before or after taking other medications, or as directed by your health care practitioner. Dosing recommendations are given for typical use based on an average 150 pound healthy adult. Healthcare practitioners are encouraged to use clinical judgement with case-specific dosing based on intended goals, subject body weight, medical history, and concomitant medication and supplement usage.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website.
We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product or Book with one of BodyCrafters Physicians / Naturopathic Doctors or a Certified Natural Product Advisor.
