GASTROMEND-HP™ 60 CAPSULES Designs for Health

$79.99 $63.99

This is a professional line item. If you are unsure of the suitability of this supplement, please Book with our Naturopathic Doctor.

GastroMend-HP™ is a blend of botanical extracts and nutrient complexes with specific antimicrobial and mucosal healing properties. It is used in herbal medicine to help relieve inflammatory conditions of the gastrointestinal tract, such as gastritis in adults. It also helps alleviate stomach pain and heartburn in association with dyspepsia.

Product Tech Sheet (PDF): gastromend-hp-techsheet

NPN: 80050586
UPC Code: ……………….

GastroMend-HP™ is a blend of botanical extracts and nutrients with gastric mucosal supportive
properties. This novel combination of substances provides a valuable tool in the management of
stomach pain and heartburn in association with functional dyspepsia and has been traditionally used to relieve inflammatory conditions of the gastrointestinal tract. It is delivered in quick-release capsules formulated for dissolution and action in the stomach and duodenum.
Mastic gum (Pistacia lentiscus) is a resinous substance from a tree native to Greece and has been used
for over 2500 years in the Mediterranean where it is chewed like gum for the purpose of ameliorating
stomach pain. Modern scientific research has validated the antimicrobial properties of mastic gum,
with human and in vitro studies showing it to be effective against E. coli and S. aureus.
2-5 Mastic gum may also have anti-inflammatory properties. In vitro studies demonstrate that mastic gum dose-dependently inhibits production of the superoxide radical and hydrogen peroxide in rodent cells treated with the inflammatory compound TNF-α. Mastic gum did not scavenge the free radicals, rather, it reduced their production, leading researchers to hypothesize that this action is likely responsible for some of the anti-inflammatory activity of mastic gum. Mastic gum has been identified as a PPAR agonist, so it may favorably affect processes that result in inflammation or oxidative stress at the level of gene expression as well.7 A randomized, double-blind trial investigating the effects of mastic gum on functional dyspepsia found that compared to placebo, mastic gum resulted in significant improvement in stomach pain in general, stomach pain when anxious, heartburn, and dull ache in the upper abdomen.8 Human and animal studies demonstrate mastic gum’s potential role in supporting the treatment of duodenal ulcers and gastric ulcers.
Methylmethionine Sulfonium (MMS) is a derivative of methionine found in raw cabbage and is often referred to as “vitamin U”, although not technically a vitamin. The use of MMS-rich raw cabbage juice has been studied extensively for its beneficial role in supporting the natural healing process of of
damaged and eroded intestinal mucosa. Human research dating back over 70 years supports the
traditional use of raw cabbage juice for dramatically improving gastric and duodenal ulcers, including
among subjects who made no other changes to their diet or medication regimens.
Deglycyrrhizinated Licorice (DGL) is a well-established mucosal supportive botanical. DGL is a
mucilaginous herb that supports healthy intestinal function by coating and soothing the intestinal lining and promoting the natural repair process of inflamed tissue. Being ultra-low in glycyrrhizin, DGL exerts its beneficial gastric effects without the potential side-effects of high-dose full-spectrum licorice consumption (e.g., hypertension, hypokalemia or fluid retention). GastroMend-HP™ provides DGL as GutGard®, a patented form of highly concentrated, flavonoid-rich licorice extract. The strong potency of GutGard® makes it effective at one tenth the dose of conventional DGL extracts for decreasing the ulcer index and increasing the pH of gastric fluid (shown in rodent models).19 An in vitro study in murine macrophages and human neutrophils showed that GutGard® inhibits synthesis of the inflammatory prostaglandin PGE2 and activity of enzymes involved in inflammation (COX and LOX).  A randomized, double-blind, placebo-controlled study evaluating the ecacy of GutGard® in adults with functional dyspepsia showed that compared to placebo, taking 150 mg of GutGard® (the amount provided in one 4-capsule serving of GastroMend-HP™) resulted in significant reduction in total symptom scores in as little as 15 days, with reduction increasing further at 30 days.21 GutGard®
promoted marked improvement or total resolution in 60% of subjects compared to over 50%
experiencing no change while taking placebo. Improvements were noted in heartburn, nausea,
belching, vomiting, regurgitation, loss of appetite, and upper abdominal fullness and pain. Contributing mechanisms may be that GutGard® improves gastric motility, significantly increases gastric emptying and improves GI transit time, as was shown in a rodent model of functional dyspepsia.
Zinc Carnosine is included in GastroMend-HP™ based on research showing zinc to have beneficial
effects for supporting gastric tissue and the mucosal layer.29 Compared to placebo, zinc carnosine was shown to neutralize the effect of the NSAID indomethacin on increasing gut permeability in healthy human subjects. (The placebo arm experienced a three-fold increase in gut permeability while the zinc-treated group showed no significant change.) In a trial of patients with small bowel injury
induced by extended use of low-dose aspirin, compared to untreated controls, subjects taking zinc
carnosine for four weeks showed significant reductions in the number of reddened lesions and erosions, confirmed by capsule endoscopy before and after. Zinc carnosine—zinc complexed with the amino acid L-carnosine in a 1:1 chelate—is the preferred form of zinc for this formula because it does not easily dissociate in stomach acid and effectively adheres to lesions, after rapid dissociation and adheres to ulcerous lesions more effectively, after which the L-carnosine and zinc are separated and have beneficial effects on the affected tissue.
Vitamin C is included for its role in tissue regeneration. Vitamin C may be effective both restoratively and prophylactically, although more evidence supports the latter. Low levels of vitamin C in serum and gastric juices have been consistently found in subjects with gastritis.34 Vitamin C deficiency is associated with all forms of gastritis, including autoimmune (pernicious anemia) and experimentally induced. Researchers note that gastric inflammation “can decimate total body ascorbic acid stores by continually quenching high levels of ascorbic acid at inflammatory sites and destroying it in a hypochlorhydric environment.”36 Since vitamin C deficiency may be as much a result as a contributor to these issues, it is prudent to include vitamin C in a formula designed for patients with gastric inflammatory conditions.
Recommended Dose: . Adults: Take 2 capsules twice a day
before a meal, or as directed by your health care practitioner. Take a few hours before or after taking
other medications. For use beyond 2 weeks, consult a health care practitioner. Dosing
recommendations are given for typical use based on an average 150 pound healthy adult. Healthcare
practitioners are encouraged to use clinical judgement with case-specific dosing based on intended
goals, subject body weight, medical history, and concomitant medication and supplement usage. Any
product containing botanical substances has the potential for causing individual sensitivities. Individual monitoring, including liver function tests, may be appropriate

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Designs For Health

About Designs for Health

Our Company Since 1989, Designs for Health has been the health care professional's trusted source for research-backed nutritional products of superior quality. By providing comprehensive support through our extensive product line, ongoing clinical education, and practice development programs, we are able to maximize the potential for successful health outcomes. Our wide array of added-value services not only set us apart, but indicate the depth of our commitment to you. Jonathan and Linda Lizotte, RD, CDN, founded Designs for Health in 1989 with a local team of nutritionists. Managing 22 Northeastern offices, the company's initial focus was to provide nutrition counseling services for the treatment of a variety of health conditions. The success of this endeavor grew, as did the demand for nutritional products to satisfy the specific treatment needs of the company's clinical nutritionists. Realizing that a genuine need existed for a line of nutritional supplements designed by health care professionals, for health care professionals, Designs for Health focused its efforts in this direction. Of utmost importance to the health professionals served by Designs for Health was ?? and still is ?? quality ingredients, efficacious doses, and company integrity. The formation of a Designs for Health branded supplement line led to mass requests from clinicians for further education and support. Advanced training courses were offered, dealing with nutritional approaches to chronic disease. To better serve its customers, Designs for Health responded in 1996 by directing its resources toward the establishment of 3 primary divisions: Professional Products, Research and Education, and Practice Development. With its roots in education, Designs for Health remains committed to providing the latest scientific nutrition research via innovative seminars and conferences. To this day, nutritionally-minded clinicians with ongoing clinical experiences shape the direction of the company. By holding itself to extremely high standards and delivering results, Designs for Health has established itself as one of the fastest growing manufacturers and distributors of nutritional supplements, selling exclusively to the health professionals market. Led by a talented and committed team of professionals whose ultimate goal is to help people lead healthier lives, Designs for Health delivers on its promise to provide the highest quality nutritional products available ?? and the dedicated relevant support needed to ensure optimal results.