NAC & ALA 90 Capsules Bioclinic Naturals

$30.99

250 mg NAC • 300 mg ALA

Benefits

  • Provides clinically relevant doses of N-acetyl-L-cysteine and alpha-lipoic acid
  • NAC and ALA have direct antioxidant action, and also enhance the synthesis and regeneration of glutathione, the key cellular antioxidant
  • Support mitochondrial function as well as phase 2 antioxidant enzyme upregulation
  • Improves endothelial function and also supports nitric oxide synthesis Reduce hyperglycemia associated damage

SKU: 9525

NPN: 80120670

UPC: 629022095254

Download Pdf info sheet: 
This is a professional line item. If you are unsure of the suitability of this supplement,

Book an appointment with one of our Naturopathic Doctors or consult with a  qualified healthcare practitioner.

SKU: 629022095254 Categories: ,

Benefits

  • Provides clinically relevant doses of N-acetyl-L-cysteine (NAC) and alpha-lipoic acid (ALA)
  • NAC and ALA have direct antioxidant action and enhance the synthesis and regeneration of glutathione, the key cellular antioxidant
  • Supports mitochondrial function as well as phase II antioxidant enzyme upregulation
  • Targets central mediators of inflammation
  • Improves endothelial function and supports nitric oxide synthesis
  • Reduces hyperglycemia-associated damage
  • Suitable for vegetarians

Feature Summary

NAC and ALA are highly complementary nutrients, critical to cellular function and mitigation of hyperglycemia-associated damage. NAC drives the synthesis of glutathione, often depleted in cardiovascular diseases and metabolic and oxidative stress conditions.1,2 NAC also has direct antioxidant activity, restores pools of intracellular thiols, and has an anti-inflammatory effect, mediated via inhibition of nuclear factor kappa B (NF-κB).3 Glutathione is needed for the detoxification of many persistent organic pollutants, compounds known to impair mitochondrial function, adipose tissue metabolism, and pancreatic islet cell function.4 In addition to glutathione support, NAC enhances antioxidant protection through multiple pathways, including upregulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) activation, suggesting a significant potential to mitigate pathology due to oxidative stress.5 Clinical trials have shown that NAC restores intraplatelet glutathione levels in certain populations – a marker of atherothrombotic risk – reduces homocysteine, and improves endothelial function in coronary artery disease (at doses of 600–1800 mg/day).6,7

ALA, in turn, recycles antioxidant nutrients such as vitamin C and glutathione, and is a cofactor for several mitochondrial enzymes as well as glutathione reductase.8 It supports glycemic control and insulin sensitivity in individuals with inadequate glucose control, endothelial function among people with impaired glucose tolerance, and weight control among obese subjects.9,10,11 It has a well-recognized benefit for mitigating the neuronal oxidative damage resulting from hyperglycemia.12,13 Clinical trial data has shown improvement in multiple markers of oxidative stress and vascular inflammation in a variety of populations.14,15 Its antioxidant and neuroprotective effects may also provide protection against neurodegeneration and a range of oxidant-associated diseases.

Medicinal Ingredients

Each Capsule Contains:
N-Acetyl-L-Cysteine 250 mg
R-Alpha-Lipoic Acid 100 mg

Non-Medicinal Ingredients

Vegetarian capsule (carbohydrate gum [cellulose], purified water), dibasic calcium phosphate dihydrate, vegetable grade magnesium stearate (lubricant), silica, stearic acid.

Dosage:

Recommended Adult Dose: 1 capsule 2 times per day with a meal or as directed by a health care practitioner.

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs. Suitable for vegetarians. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Contraindications

Avoid use with acetylcysteine allergy and use with caution in individuals with asthma.

Drug Interactions

ALA was shown to prevent drug-induced weight gain associated with atypical antipsychotics without reducing drug efficacy.18,19 Caution should be used with anti-diabetes medications, as they may have additive hypoglycemic effects. Long-term use may warrant low dose copper and/or thiamine supplementation. Although NAC may reduce nitroglycerin tolerance and improve its efficacy for unstable angina, severe headaches and hypotension may occur. NAC may also reduce the capacity of activated charcoal to absorb acetaminophen. NAC is shown to prevent the drop in GSH following acetaminophen use, without interfering with antinociceptive effects.20

This is a professional line item. If you are unsure of the suitability of this supplement,

Book an appointment with one of our Naturopathic Doctors or consult with a  qualified healthcare practitioner.

Alternative Option

Brand

Bioclinic Naturals

At Bioclinic Naturals, we offer an exclusive health care practitioner line of evidence-based natural health products. Each formula is developed by the industry leading, outstanding scientists and health care practitioners on our Scientific Advisory Board to meet, and exceed, the needs of your patients. Every great product starts with the best ingredients. Our goal is to provide the best quality, tested raw materials. We have certified organic farmland in Canada’s Okanagan Valley, and whenever possible we grow our own plant-based ingredients. Any raw material we do not produce ourselves is subjected to the highest level of scrutiny to ensure the quality and purity. We are Canada’s leading nutraceutical manufacturer. We have state-of-the-art manufacturing facilities that include tabulating and softgel encapsulation. Our standards meet or surpasses the Canadian Good Manufacturing Practices (GMPs) established by the Natural and Non-Prescription Health Products Directorate (NNHPD) of the Canadian Federal Government, and Canadian Food Inspection Agency (CFIA) regulations. Our products also meet or exceed other international standards including the US Federal Drug Administration (FDA), the US Pharmacopeial Convention (USP), the Korean Ministry of Health and Welfare (MHW), and the Australian Therapeutic Goods Administration (TGA). Our commitment to quality is reflected in the our investment in expanding our in-house Quality Control, Quality Assurance, and Research & Development departments, allowing us to verify the purity, potency, and efficacy of each and every product. We have advanced analytical technology and equipment, including HPLC and Mass Spectrometry, and can test for over 400 contaminants down to the molecular level. We adhere strictly to good laboratory practices (GLP), and our products are ISURA certified. This third party certification tests for non-GMO, contaminants, and identity. Bioclinic Naturals’ focus is on clinical application for nutritional interventions and strategies for preventive medicine. Our unique formulas meet practitioners’ needs for both condition-specific challenges and overall health enhancement. Our continual commitment to product quality in every stage of production for every product ensures that our products have earned the trust of practitioners and their patients. We work closely with our Scientific Advisory Board to ensure that our products live up to their claims. Their scientific investigation focuses on the clinical application of our products, as well as nutritional interventions and strategies for preventive medicine. At Bioclinic Naturals, we don’t just say that we provide the most effective natural health products – we prove it. We have the science and clinical research to back up our products for quality, potency, and effectiveness.

Related products