NOx Synergy™ is a comprehensive formula designed to optimize nitric oxide (NO) levels in the body. It is provided in a delicious berry flavoured powder for convenient dosing and ease of patient compliance.
ARGININE AND CITRULLINE
Arginine is a critical substrate for the synthesis of NO, a compound that relaxes endothelial cells throughout the cardiovascular system. NO also inhibits platelet aggregation and superoxide radical generation. Arginine supplementation has been shown to reverse the endothelial dysfunction associated with common cardiovascular risk factors and also ameliorates symptoms of certain cardiovascular disorders, including coronary and peripheral arterial disease, ischemia/reperfusion injury and heart failure. Supplemental arginine may be beneficial due to high arginase activity in the small intestine, where approximately 40% of arginine is degraded during digestion, and only 50% of dietary arginine enters the systemic circulation.1 Citrulline is included as an adjunct to arginine, as citrulline is converted to arginine in various cells. Unlike arginine, citrulline is not metabolized in the intestine or liver and does not induce tissue arginase. In fact, it inhibits arginase, and citrulline entering peripheral tissues—particularly the kidneys and vascular endothelium—may be readily converted to
arginine, thus raising arginine levels and enhancing NO production.2 Studies show that citrulline raises plasma arginine levels significantly higher than arginine itself and has a longer half-life in the body, so citrulline can be thought of as a potent “time-released arginine.” Research suggests that one of citrulline’s primary physiological roles is serving as a precursor to arginine in the kidneys. In regard to the influence of citrulline on increasing NO synthesis and stimulating a positive downstream effect, a study involving men with mild erectile dysfunction demonstrated that 1.5g/day of citrulline improved erectile function in 50% of participants. NOx Synergy™ includes glutathione as an adjunct to citrulline. The combination of these compounds has been shown to increase plasma levels of NO in humans in vivo. It may be particularly beneficial for recovery from intense physical activity and may enhance muscle protein synthesis after resistance training.
Arginine is a critical substrate for the synthesis of NO, a compound that relaxes endothelial cells throughout the cardiovascular system. NO also inhibits platelet aggregation and superoxide radical generation. Arginine supplementation has been shown to reverse the endothelial dysfunction associated with common cardiovascular risk factors and also ameliorates symptoms of certain cardiovascular disorders, including coronary and peripheral arterial disease, ischemia/reperfusion injury and heart failure. Supplemental arginine may be beneficial due to high arginase activity in the small intestine, where approximately 40% of arginine is degraded during digestion, and only 50% of dietary arginine enters the systemic circulation.1 Citrulline is included as an adjunct to arginine, as citrulline is converted to arginine in various cells. Unlike arginine, citrulline is not metabolized in the intestine or liver and does not induce tissue arginase. In fact, it inhibits arginase, and citrulline entering peripheral tissues—particularly the kidneys and vascular endothelium—may be readily converted to
arginine, thus raising arginine levels and enhancing NO production.2 Studies show that citrulline raises plasma arginine levels significantly higher than arginine itself and has a longer half-life in the body, so citrulline can be thought of as a potent “time-released arginine.” Research suggests that one of citrulline’s primary physiological roles is serving as a precursor to arginine in the kidneys. In regard to the influence of citrulline on increasing NO synthesis and stimulating a positive downstream effect, a study involving men with mild erectile dysfunction demonstrated that 1.5g/day of citrulline improved erectile function in 50% of participants. NOx Synergy™ includes glutathione as an adjunct to citrulline. The combination of these compounds has been shown to increase plasma levels of NO in humans in vivo. It may be particularly beneficial for recovery from intense physical activity and may enhance muscle protein synthesis after resistance training.
NOX SYNERGY™ MAY HELP TO:
• increase the body’s production of NO
• extend the half-life of NO in the body
• protect NO from producing peroxynitrites (harmful free radicals)
• enhance the production of ATP
• increase the body’s production of NO
• extend the half-life of NO in the body
• protect NO from producing peroxynitrites (harmful free radicals)
• enhance the production of ATP
BENEFITS OF NOX SYNERGY™
Athletic performance: by increasing blood flow to muscles and enhancing ATP production, exercise can be performed at a higher intensity for a longer duration; muscle contraction may be more effcient, potentially leading to a greater anabolic effect. Additionally, antioxidants in NOx Synergy™ may help aid recovery from intense athletics.
Athletic performance: by increasing blood flow to muscles and enhancing ATP production, exercise can be performed at a higher intensity for a longer duration; muscle contraction may be more effcient, potentially leading to a greater anabolic effect. Additionally, antioxidants in NOx Synergy™ may help aid recovery from intense athletics.
Recommended Dose: Adults: Mix one scoop/approx. 2 tsp. in 8-10 oz of water immediately before consumption. Take once per day or as directed by a health care practitioner.
Dosing recommendations are given for typical use based on an average 150 pound healthy adult. Healthcare practitioners are encouraged to use clinical judgement with case-specific dosing based on intended goals, subject body weight, medical history, and concomitant medication and supplement usage.
Dosing recommendations are given for typical use based on an average 150 pound healthy adult. Healthcare practitioners are encouraged to use clinical judgement with case-specific dosing based on intended goals, subject body weight, medical history, and concomitant medication and supplement usage.
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