OmegAvail™ Ultra DHA contains highly concentrated DHA from fish oil in its natural TG (triglyceride) form. As with all DFH TruTG™ fish oil products, OmegAvail™ Ultra DHA is comprised of a minimum 90% natural TG-bound omega-3 oils. Each softgel provides 500 mg DHA + 110 mg EPA for optimal DHA status. DHA (docosahexaenoic acid) is an omega-3 fatty acid which plays an important role in human physiology and is thought to have had a large impact on human evolution. DHA is not technically an essential fatty acid since the human body can synthesize very small, although insignificant, amounts of it from its short chain omega-3 precursor ALA (alpha linolenic
acid) with approximately 0.1-1% efficiency.26,35 However, there is ample evidence which shows that in order to support optimal health and alleviate various pathological conditions, additional DHA along with EPA (eicosapentaenoic acid) should be obtained from diet and/or nutritional supplements.
acid) with approximately 0.1-1% efficiency.26,35 However, there is ample evidence which shows that in order to support optimal health and alleviate various pathological conditions, additional DHA along with EPA (eicosapentaenoic acid) should be obtained from diet and/or nutritional supplements.
Physiological roles of DHA
1. DHA is a structural molecule in all cell membranes. It provides the highest fluidity possible due to it having the greatest number of double bonds among all polyunsaturated fatty acids. This makes the cell membranes very receptive to surrounding signals produced by other cells, such as neurotransmitters, immune signals and hormones.
• DHA is an important component of neuronal cell membranes (40% of total PUFA content), where it is complexed with phosphatidylserine, phosphatidylethanolamine and phosphatidylcholine.
1. DHA is a structural molecule in all cell membranes. It provides the highest fluidity possible due to it having the greatest number of double bonds among all polyunsaturated fatty acids. This makes the cell membranes very receptive to surrounding signals produced by other cells, such as neurotransmitters, immune signals and hormones.
• DHA is an important component of neuronal cell membranes (40% of total PUFA content), where it is complexed with phosphatidylserine, phosphatidylethanolamine and phosphatidylcholine.
• DHA is an important component of the eye’s retinal epithelial cells and photoreceptors in the macula. It is critical to vision and comprises 35% of fatty acids in the photoreceptors.15,30
• As a component of mitochondrial membranes, DHA supports better ATP production by enhancing the electron transport system, as demonstrated in heart cells48 and brain cells.38
2. DHA is a precursor to docosanoids (regulating molecules): Docosanoids are similar in structure to the eicosanoids derived from EPA and have anti-inflammatory, immune regulatory and protective actions in the context of various inflammatory responses. Two types of docosanoids:
• Neuroprotectin D1 – specific to brain protection against ischemia, oxidative stress
• Resolvins D1-D4 – produced during the resolution phase of acute inflammation and support adequate termination of inflammatory processes throughout the body.
• As a component of mitochondrial membranes, DHA supports better ATP production by enhancing the electron transport system, as demonstrated in heart cells48 and brain cells.38
2. DHA is a precursor to docosanoids (regulating molecules): Docosanoids are similar in structure to the eicosanoids derived from EPA and have anti-inflammatory, immune regulatory and protective actions in the context of various inflammatory responses. Two types of docosanoids:
• Neuroprotectin D1 – specific to brain protection against ischemia, oxidative stress
• Resolvins D1-D4 – produced during the resolution phase of acute inflammation and support adequate termination of inflammatory processes throughout the body.
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