Prenatal Pro™ is a four-a-day multivitamin/multimineral designed to provide a broad foundation of nutrients to augment and complement an average diet. Its formulation was guided by established Recommended Dietary Allowances (RDAs) and Adequate Intakes (AIs), average nutrient consumptions and common insufficiencies in typical Western diets, and intensive support for a healthy pregnancy and optimal fetal development. Prenatal Pro™ is unique as it contains a blend of gamma and delta-tocotrienols, which are more potent antioxidants than alpha-tocopherol and have unique health benefits. (See the tech sheet for Annatto-E™ for details.) It also includes a bioidentical form of folate with superior bioavailability compared to folic acid, which may mitigate effects of common genetic polymorphisms on increased risk of birth defects. The optimal intake of vitamins and minerals for pregnant women or women trying to conceive is a topic of ongoing research. This includes evaluation of the diet that humans evolved on for millions of years1-4, as well as research that proposes to redefine the minimum levels of nutrients that support healthy DNA replication (also referred to as genomic stability). This is relevant to pregnant women’s health and to fetal development.5-8 The newly proposed Australian RDA for folate (700
mcg) is higher than the US RDA (600 mcg dietary folate equivalents) but similar to the estimated average evolutionary intake of dietary folate of 736 mcg. In addition, beyond nutrient intakes recommended for broad swaths of general populations, it is sensible to take into account clinical status, age, and genetics when estimating required nutrient intakes. For example, as one study points out, polymorphisms related to the folate/homocysteine pathway may contribute to increased risk for a number of pregnancy-related pathologies.9 The
levels of vitamins B2, B6, B12 and folate found in Prenatal Pro™ are adequate for maintaining healthy homocysteine (Hcy) levels for a large section of the population but not for those with single nucleotide polymorphisms in particular Hcy metabolic pathways and/or folate receptor activity.10-12
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