5 • HTP Supreme™
5-Hydroxytryptophan (5-HTP) is a precursor to serotonin biosynthesis. It is produced from the essential amino acid L-tryptophan which is naturally supplied by dietary proteins such as turkey and milk and requires vitamin B6 as a cofactor. 5 • HTP Supreme™ is produced primarily in either the enterochromffin cells of the gastrointestinal tract or the midline raphe nuclei of the brainstem where it is then converted to serotonin. Serotonin produced in the gastrointestinal tract stimulates physiologic functions including vasoconstriction, uterine contraction, bronchoconstriction, gastrointestinal motility, and platelet aggregation. In the brain, serotonin inhibits excitatory neurotransmission and modulates wakefulness, attention, affective behavior (anxiety and depression), sexual behaviour, appetite, thermoregulation, motor tone, migraine, emesis, nociception, and aggression.
• Mood disorders
• Excessive appetite
• Binge eating
• Carbohydrate cravings
• Obesity
• Headaches
• Migraines
• Insomnia
• Fibromyalgia
• Neuropathic pain
• Irritable Bowel Syndrome
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