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Allicillin™ 60 Softgels Designs for Health

$42.00

This is a professional line item. If you are unsure of the suitability of this supplement, please Book with our Naturopathic Doctor.

Allicillin™ softgels are enteric coated so as to lessen the strong garlic odour and repeating that sometimes occurs from supplementing garlic. Used in herbal medicine to help maintain cardiovascular health and reduce elevated blood lipid levels in adults, and to relieve the symptoms associated with upper respiratory tract infections and catarrhal conditions.

GLUTEN FREE /DAIRY FREE /NON-GMO
SKU: ALLS60-CN
NPN: 80073591

UPC Code: ……………….

SKU: V6B4OZ-CN-1 Categories: , Tag:
Allicillin™ softgels contain 200 mg of Garlicillin®, a blend of garlic oil and parsley oil with specified levels of garlic sulfides and ajoene, highly bioactive compounds formed from garlic. These softgels are enteric coated to reduce the strong garlic odor and repeating that may occur from supplementing with garlic. The parsley oil further helps as a natural breath freshener.
The phytochemistry of garlic is complex, but research shows that garlic’s unique organosulfur compounds are responsible for its broad range of health benefits. The best known and studied of these bioactive compounds is allicin. Through its decomposition, allicin breaks down to form a variety of organosulfur compounds, which include garlic sulfides—diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS) —and ajoene, as found in Allicillin™ softgels.
HIGHLIGHTS: AJOENE & SULFIDES
Ajoene (from “ajo,” the Spanish word for garlic) is a natural product of allicin degredation in oil, and it is considered one of the most bioactive and stable allicin metabolites.1,42 Research studying ajoene showed its ability to inhibit platelet aggregation through various mechanisms — blocking tyrosine phosphatase activity in human platelets, enhancing platelet-derived nitric oxide, and preventing platelets’ ability to bind to fibrinogen by interacting with GPIIb/IIIa receptors.
The antimicrobial (antibacterial and antifungal) properties of ajoene have received considerable attention. Studies show that ajoene exhibits broad spectrum antimicrobial activity against growth of gram-positive bacteria such as Bacillus cereus, B. subtilis, Mycobacterium smegmatis, Streptomyces griseus, Staphylococcus aureus, and Lactobacillus plantarum Growth of gram-negative bacteria such as Escherichia coli, Klebsiella pneumonia and Xanthomonas maltophilia is also inhibited by ajoene, although at higher doses than for the gram-positive strains.
Ajoene is more effective than allicin against Aspergillus niger and Candida albicans10 at <20mcg/ml, due in part to its ability to block lipid synthesis. In clinical studies ajoene was shown to be as effective or better than the common antifungal, ketoconazole, when tested on C. albicans, Aspergillus, Malassezia furfur, Cryptococcus and other Candida species and shown to externally treat ringworm, skin parasites, and warts, as well tinea pedis (athlete’s foot). Ajoene has been shown to be more effective than sulfametoxazol/trimethoprim, a combination antibiotic, in mice with Paracoccidioides brasilensis. Additionally, one study revealed the mechanism in which ajoene-induced ROS (reactive oxygen species), ER (endoplasmic reticulum) stress and macrophage autophagy has on reducing Mycobacterium tuberculosis in vitro.14 The antiparasitic and cytostatic action of ajoene inhibits T. cruzi, trypanothione reductase and glutathione reductase activity, key antioxidant thiol metabolism enzymes.
Ajoene and other garlic extracts were tested in vitro against several viruses, including human Cytomegalovirus, influenza B, Herpes simplex types 1 and 2, Parainfluenza virus type 3, vaccina virus, vesicular stomatitis virus, and human rhinovirus type 2, as well as the common cold virus. Ajoene was found to have the greater virucidal activity than allicin and the other garlic extracts tested. Ajoene also demonstrates chemopreventive properties due to its ability to arrest cancer cell progression, increase tumor suppressor gene expression, inhibit angiogensis and modulating various other genetic pathways that induce cancel cell apoptosis. Ajoene has also been shown to target Glioblastoma Multiforme cancer stem cells, as well as, targeting and modifying the vimentin protein in cancer cells which contributes to the anti-metastatic and anti-proliferative effects of this garlic derivative.
An in vitro study examining the effect ajoene has on intestinal IgA in mice showed an increase in fecal IgA just after 3 weeks of administration, suggesting that ajoene may enhance mucosal immune function.
GARLIC SULFIDES
Garlic sulfide compounds—diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS)—have an extensive body of research supporting their efficacy across a wide range of actions. They may be beneficial for cardiovascular health, as they have been shown to protect against oxidation of LDL particles in humans. In a randomized trial that assessed the potential for aged garlic extracts to reduce the progression of coronary atherosclerosis, after 12 months of treatment, the increase in adipose tissue around the heart, lungs, and vital organs was significantly lower than the control group, which is a well-known mediator of metabolic risk. In another study, after 14 days of administration in cardiac hypertrophy-induced rats, garlic and DADS activates mitochondrial synthesis and alleviates cardiac hypertrophy by enhancing mitochondrial endothelial nitric oxide synthase activity, protein kinase B and antioxidant-protective gene expression NRf2 and Tfam.
A meta-analysis of RCTs showed that supplemental administration of garlic significantly lowered fasting blood glucose, plasma fructosamine, and hemoglobin A1c compared to the controls leading researchers to conclude that these garlic-derived sulfur compounds may benefit patients with diabetes-related vascular complications.
Similar to ajoene, garlic sulfides exhibit antimicrobial activity. In an in vitro study, researchers examined the antimicrobial activities of fresh garlic extract (FGE) upon multi-drug resistant strains, finding FGE to exhibit strong inhibition properties against methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans suggesting that DAS and DADS could help improve antibiotic sensitivity of pathogens to certain antibiotics and aid treatment of infections. Another in vitro study showed that the normal metabolism and function of C. albicans was disrupted in response to the garlic oil treatment after only one day of incubation, further providing more evidence on garlic’s excellent antifungal properties. It may be reductions in overall inflammation and these glycoproteins involved in blood clotting that underlie garlic’s well-recognized antithrombotic and anti-platelet aggregation properties. DADS and DATS have been shown to reduce lipopolysaccharide-induced inducible nitric oxide synthase, nitric oxide production, oxidative stress, and activation of NF-kappaB as well as reduce lipid peroxidation in human epithelial cells, suggesting DAS is effective in recovering cell viability and abating DNA damage.
Another study demonstrates DAS’ role as a cytochrome P450 2E1 enzyme inhibitor capable of preventing cellular toxicitiesfrom xenobiotics, alcohol, and analgesic drugs, as well as, from diseases such as HIV, cancer, diabetes/hyperlipidemia, and Parkinson’s disease.  The anti-inflammatory effects of garlic sulfides extend to reducing inflammatory markers in a murine model of inflammatory bowel disease.  Additional anti-inflammtory effects of garlic sulfides include protecting against NSAID-induced enteropathy and dysbiosis, oxidative stress-induced inflammation of the airway via inhibiting TNF-alpha and histamine-induced inflammation in A7r5 cells, as well as periodontal Porphyromonas gingivalis.
WHY NOT ALLICIN?
The use of garlic sulfides and ajoene in Allicillin™, rather than standard allicin, was arrived at after careful consideration of the many problematic aspects of providing allicin in supplement form. Allicin is not present in fresh, intact garlic cloves. The predominant sulfur compound in whole, undamaged garlic is alliin. The alliinase enzyme, present in high levels in garlic, is contained in a separate compartment of the garlic, and it only acts upon its alliin substrate when the plant is injured. When fresh garlic cloves are crushed or chopped, or when garlic powder (that has been carefully dried to preserve its alliin/alliinase content) is added to water, allicin is quickly produced by the action of alliinase on alliin.
Many dietary supplement companies claim to provide a product that delivers allicin.  Allicin is often listed on labels as “allicin yield,” or “allicin potential,” reflecting the compound’s instability and the inability to specify and guarantee allicin content and potency. Allicin potential is measured in laboratories using dried garlic powder that is added to water so that the alliin and allinase can quickly react to form allicin. The amount of allicin produced is the measure of allicin potential. However, this laboratory assay does not accurately reflect production of allicin when such garlic supplements are swallowed. The allinase enzyme is rapidly and completely destroyed by stomach acid, and allicin cannot be made from alliin in the absence of active allinase. Some garlic products claim to address this issue by using an enteric coated delivery method. Unfortunately, such methods have unimpressive efficacy. In a report of testing twenty-three enteric coated U.S. garlic supplements, twenty of the twenty-three failed to release even 15% of their claimed “allicin potential” when placed in simulated intestinal fluid. The study authors concluded that allicin potential is a poor measure of garlic supplement activity in the human body and should not be used for the standardization of garlic supplements. Considering the questionable utility of allicin potential, Allicillin™ was developed to contain sulfides and ajoene, the inherently stable metabolites of allicin.
WHO SHOULD TAKE ALLICILLIN™?
Patients with recurring yeast infections, bacterial or viral infections, lipid abnormalities, platelet aggregation, inflammation, immune deficiency and/or history of heart disease. Consider Allicillin™ supplementation during antibiotic usage to prevent yeast overgrowth, a common side effect of antibiotic therapy. Allicillin™ has blood thinning capabilities and reduces platelet aggregation. Be cautious when recommending this product to patients taking Coumadin, Warfarin or other anticoagulant medications.
HEALTH BENEFITS OF AJOENE MAY INCLUDE:
• anti-bacterial activity
• anti-viral activity
• anti-fungal activity
• anti-inflammatory properties
Medicinal Ingredients (per softgel):
Garlicillin® (Garlic Essential Oil [Allium sativum-Bulb] and Parsley oil (Petroselinum crispum-Seed) blend containing 20 mg garlic diallyl sulfide, diallyl disulfide, diallyl trisulfide and ajoene) ……200 mg
Non-Medicinal Ingredients: Olive oil, yellow beeswax, sunflower lecithin, bovine gelatin, glycerine, purified water, annatto (natural colour), pharmaceutical glaze, sodium alginate (softgel ingredients).
Recommended Dose: Adults: Take 1 softgel
once per day, or as recommended by your health care practitioner.

 

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Designs For Health

About Designs for Health

Our Company Since 1989, Designs for Health has been the health care professional's trusted source for research-backed nutritional products of superior quality. By providing comprehensive support through our extensive product line, ongoing clinical education, and practice development programs, we are able to maximize the potential for successful health outcomes. Our wide array of added-value services not only set us apart, but indicate the depth of our commitment to you. Jonathan and Linda Lizotte, RD, CDN, founded Designs for Health in 1989 with a local team of nutritionists. Managing 22 Northeastern offices, the company's initial focus was to provide nutrition counseling services for the treatment of a variety of health conditions. The success of this endeavor grew, as did the demand for nutritional products to satisfy the specific treatment needs of the company's clinical nutritionists. Realizing that a genuine need existed for a line of nutritional supplements designed by health care professionals, for health care professionals, Designs for Health focused its efforts in this direction. Of utmost importance to the health professionals served by Designs for Health was ?? and still is ?? quality ingredients, efficacious doses, and company integrity. The formation of a Designs for Health branded supplement line led to mass requests from clinicians for further education and support. Advanced training courses were offered, dealing with nutritional approaches to chronic disease. To better serve its customers, Designs for Health responded in 1996 by directing its resources toward the establishment of 3 primary divisions: Professional Products, Research and Education, and Practice Development. With its roots in education, Designs for Health remains committed to providing the latest scientific nutrition research via innovative seminars and conferences. To this day, nutritionally-minded clinicians with ongoing clinical experiences shape the direction of the company. By holding itself to extremely high standards and delivering results, Designs for Health has established itself as one of the fastest growing manufacturers and distributors of nutritional supplements, selling exclusively to the health professionals market. Led by a talented and committed team of professionals whose ultimate goal is to help people lead healthier lives, Designs for Health delivers on its promise to provide the highest quality nutritional products available ?? and the dedicated relevant support needed to ensure optimal results.