Annatto-E 300 designs for health

Annatto-E™ 300 is a unique tocopherol-free, tocotrienols-only product, featuring tocotrienols sourced from the annatto tree. Annatto is the richest known source of tocotrienols, containing 100% tocotrienols (90% delta and 10% gamma isomers), with no tocopherols. Annatto-E™ 300 contains 300 mg per softgel of delta/gamma tocotrienols. Commercial vitamin E supplements are typically rich in tocopherols and low or absent in tocotrienols; however, tocotrienol fractions have unique beneficial effects across a variety of tissues that make them desirable for supporting many aspects of health. Research indicates that tocopherols; especially alpha-tocopherol, may interfere with key therapeutic effects of tocotrienols, so it may be best to dose tocotrienols alone, without tocopherols.

Vitamin E research has come a long way in recent decades. Vitamin E is not a single nutrient, but rather a complex comprising 4 tocopherols and 4 tocotrienols. Each of these components has a different molecular weight and slightly different chemical structure, which impart distinct properties that influence their biochemical functions. Commercial supplements are typically rich in tocopherols—alpha-tocopherol, in particular—but the tocotrienol fractions have unique effects across a variety of tissues that make them desirable to supplement alone, without tocopherols.
Rich sources of vitamin E include whole grains, such as wheat (especially the germ), rice, barley, oats and corn, as well as palm fruit and annatto. Most of these foods, however, are higher in tocopherols than in tocotrienols (T3). The vitamin E in rice, for example, is comprised of 50% tocopherols, 35% delta- and gamma-T3, and 15% alpha- and beta-T3, which are less potent than the delta and
gamma forms. Palm is a bit higher in tocotrienols: 25% tocopherols, 25% alpha- and beta-T3, and 50% delta- and gamma-T3. But the richest known source of naturally occurring tocotrienols is annatto, which is virtually free of tocopherols and contains 100% tocotrienols (90% delta and 10% gamma). The tocotrienols in Annatto-E™ are sourced from annatto, so they’re exclusively tocotrienols. This was a deliberate choice by Designs for Health, because research indicates that tocopherols—especially alpha-tocopherol—interfere with key effects of tocotrienols, so
it may be best to dose tocotrienols alone, or with 6 hours between tocotrienols and products containing alpha-tocopherol. (See “Why No Tocopherols?” below.) The tocotrienols in this product are provided as Delta Gold®, a patented tocotrienol formula from American River Nutrition. It is manufactured in the US and has GRAS status from the FDA.

Recommended Dose: Adults: Take one softgel per day, or as directed by your health care practitioner

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