Many people believe that the health of the gastrointestinal tract is the best indicator of an individual’s overall wellbeing. Indeed, the human digestive tract is a key modulator of the immune system and it is responsible for not only absorbing nutrients from food but also eliminating hormones, food waste and other metabolic byproducts. If this system slows down, such as in cases of functional constipation, it can indirectly have a negative effect on all of these systems. In severe cases, sluggish bowels can contribute to a complicated syndrome known as Small Intestinal Bacterial Overgrowth (SIBO).
SIBO can occur as a result of many inciting factors and the healing process is complex. However, at the core of its presentation, there is decreased function of the migrating motor complex (MMC). The MMC is an entity of the enteric nervous system responsible for promoting peristalsis in the smooth muscles of the digestive tract. Proper recovery from SIBO requires repair of the MMC and not simply stimulant laxatives. Fortunately, various nutrients have demonstrated promising results in reactivating this connection between the nervous system and the gastrointestinal tract.
One therapy with promising clinical trials as a prokinetic agent is a proprietary blend of Zingiber officinalis (ginger root) and Cynara cardunculus (artichoke root) that has two human clinical trials for improving digestive function. A double-blind placebo-controlled randomized study found that this combination therapy significantly improved symptoms of functional dyspepsia such as epigastric fullness, bloating, early satiety, nausea, vomiting and epigastric pain after both 14 and 28 days. A second trial found that the patented blend of ginger and artichoke improved gastric emptying after a meal by 24% in healthy individuals as per endoscopic evaluation. These effects on gastric emptying seem to be mediated by gingerol’s activity on cholinergic and serotonergic receptors, in combination with artichoke root’s antispasmodic and choleretic action.
Considering that ginger facilitates gastric emptying and stimulates the migrating motor complex by modulating serotonin, it only stands to reason that other agents designed to increase serotonergic activity may also be useful for improving gastrointestinal motility. As a matter of fact, both 5-hydroxytryptophan (5-HTP), the key precursor molecule to endogenously build serotonin, and vitamin B6, an essential cofactor in
this same process, have been used to encourage the rebuilding of the migrating motor complex.
Zinc has been identified for its ability to support the vagus nerve function. The vagus nerve is the most potent promoter of the parasympathetic nervous system which is responsible for “rest and digest” functions such as peristalsis. Zinc also supports epithelial barrier function, gastric acid production and aids in digestive concerns such as diarrhea.
Acetyl-L-Carnitine is commonly used for boosting cognitive function through its ability to cross the blood-brain barrier and enter the central nervous system. However, carnitine is beneficial for many organ systems. Low carnitine levels in the body have actually been correlated to increased incidence and severity of constipation. Carnitine supplementation has been studied to reduce the severity of constipation in those suffering from poor gut motility and, therefore, is a reasonable nutrient to consider in those recovering from SIBO.
GI-Motility Matrix by Cyto-Matrix provides a well-balanced blend of herbal extracts and nutrients to promote proper gastric emptying and gastrointestinal motility. GI-Motility Matrix includes the patented and researched blend of artichoke extract and ginger extract, with additional 5-HTP, zinc, vitamin B6 in its active pyridoxal-5-phosphate form and acetyl-l-carnitine. Collectively, GI-Motility Matrix is an essential formulation for any SIBO recovery protocol, constipation, dyspepsia or irritable bowel syndrome.
| Ingredient |
Amount |
|
| Ginger extract (rhizome, Zingiber officinale) 17:1, DHE 226.6mg |
13.33 mg |
|
| Ginger extract (rhizome, Zingiber officinale) 10:1, DHE 616.6mg |
61.66 mg |
|
| Globe Artichoke extract (leaf, Cynara cardunculus) 10:1, DHE 666.6mg |
66.66 mg |
|
| N-Acetyl-L-carnitine HCL |
200 mg |
|
| L-5-HTP (seed, Griffonia simplicifolia) |
20 mcg |
|
| Zinc (TRAACSTM zinc bis-glycinate chelate)* |
5 mg |
|
| Vitamin B6 (pyridoxal-5-phosphate) |
5 mg |
|
| *Mineral chelate supplied by Albion Laboratories, Inc. TRAACSTM and the Albion Gold Medallion design are registered trademarks of Albion Laboratories, Inc. Chelate covered by U.S. Patent 7,838,042. |
|
|
Unit of Measure above: Each capsule
Non-Medicinal Ingredients: Vegetable-grade magnesium stearate, dicalcium phosphate, silicon dioxide, crosscarmellose sodium, maltodextrin, microcrystalline cellulose, citric acid. Capsule: hypromellose.
Indications: Used in Herbal Medicine as a choleretic to help relieve digestive upset, such as indigestion, and help increase bile flow. Ginger is traditionally used in Herbal Medicine as a carminative to help relieve digestive disturbances including lack of appetite, nausea, digestive spasms, indigestion, dyspepsia and flatulent colic.
Directions: Adults – Take 1 capsule, 3 times per day with food or as directed by a healthcare professional. Take a few hours before or after taking other medications or natural health products.
Contradictions: Consult a healthcare professional prior to use if you are pregnant or breastfeeding. Do not use this product if you have scleroderma or a bile duct obstruction.
Warnings: Do not use if safety seal is broken. Consult a healthcare professional if you have liver disease, kidney disease and/or a seizure disorder or if you have gallstones or if you are taking carbidopa or drugs/supplements with serotonergic activity. These may include, but are not limited to, L-tryptophan, Sadenosylmethionine (SAMe), St. John’s wort, antidepressants, pain killers, over the counter cough and cold medication containing dextromethorphan, anti-nausea medication and anti-migraine medication. Stop use and consult a healthcare professional if you show signs of weakness, oral ulcers, abdominal pain accompanied by severe muscle pain or if you experience skin changes. Avoid taking with alcohol or products that cause drowsiness. Consult a healthcare professional if symptoms persist or worsen.
Known Adverse Reactions: Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. May cause digestive problems and some people may experience diarrhoea, abdominal pain, nausea, and vomiting. Hypersensitivity/allergy may occur; in which case, discontinue use.
Brand
Cyto Matix
Why Choose Cyto-Matrix?
We are 100% committed to helping you improve lives.
Cyto-Matrix's products
The excellent clinical results that are achieved with our products, combined with our honest and ethical approach, has earned Cyto-Matrix the trust of many of the most scrutinizing Canadian health care practitioners. We are appreciative and honoured that new clients of Cyto-Matrix quickly become loyal clients and are open to building a lasting relationship with us.
Our philosophy is simple; purity, integrity, innovation:
Purity
Products are developed using the highest grade possible raw materials with vegetable capsules while minimizing the use of excipients.
All products are manufactured in state-of-the-art, Good Manufacturing Practices (GMP)-compliant Canadian facilities, meeting or exceeding pharmaceutical and Health Canada standards.
Third-Party tested with rigorous QA/QC.
Integrity
All formulations are researched and designed by Naturopathic Doctors based on Health Canada-approved, evidence based science.
Products are fully licensed with approved Health Canada label claims.
All associates are required to adhere to the high ethical standards of the organization.
Customer Service Representatives will refer technical questions to staff doctors, with accurate, fast-as-possible turn around.
Innovation
Cyto-Matrix is continually researching and adding cutting-edge formulas to meet the unique and changing needs of your patients.
Expertise and innovation are shared through seminars, blog articles and Practice Pearls to aid in professional development and continuing education.
Regular feedback from practiticing professionals and our National Advisory Board is an integral part of our innovation. Do share your feedback and ideas!
Quality Manufacturing
Cyto-Matrix products are manufactured in state-of-the-art Canadian facilities in Quebec and Ontario.
Cyto-Matrix's manufacturing facility
These facilities hold valid Site Licenses as per the requirements of Health Canada's Natural Health Product Directorate. In accordance with these guidelines, sites must have procedures in place for distribution records and product recalls and for the handling, storage and delivery of their products. They must also demonstrate that they meet Good Manufacturing Practice (GMP) requirements.
The Quality Assurance Department
This department is responsible for the development of Standard Operating Procedures (SOP's). The main goal here is to ensure the integrity of the result of the finished product. All SOP's ensure compliance with GMP requirements. Other responsibilities include:
Editing of protocols and installation, operation and performance qualification implementation
Validation of HVAC, purified water and other systems
Validation of production of lab equipment
Validation of process including manufacturing/cleaning/sterilizing
The Quality Control Department
Quality Control is done throughout the manufacturing process to ensure that the finished product meets the pre-determined specifications for micro-biological and physiological criteria. Raw materials are specifically tested to ensure the highest level of quality.
The Validation Department
Working closely with the QA and QC departments, the Validation department ensures compliance with all regulations and industry standards. In particular, the main responsibilities of this department are:
Editing of protocols and installation, operation and performance qualification implementation
Validation of HVAC, purified water and other systems
Validation of production of lab equipment
Validation of process including manufacturing/cleaning/sterilizing
Cyto-Matrix Inc. is dedicated to sourcing the highest quality of raw materials available on the global market. It is the combination of high quality raw materials and strictly adhered to GMP practices, which make Cyto-Matrix products of a superior class in the natural health products market.
