Relax and Reclaim Sleep with MetaSleep
MetaSleep is formulated with Noble Kava root extract known as KavatonTM and sustained release melatonin to
facilitate a tranquil, calm state to help reset the body’s natural sleep-wake cycle and increase the total sleep
time. Sustained released melatonin mimics the natural 8 hours of sleep pattern, releasing 50% melatonin in
the first hour, with subsequent release per hour in smaller doses and finally tapering off after 6 hours.
Melatonin: The Sleep Hormone
What is melatonin? How does melatonin work in the body?6
Melatonin is a hormone produced by the pineal gland in the brain at night. It regulates the sleep-wake
cycle, signaling to your body when it’s time to wind down and prepare for sleep. It synchronizes the
circadian rhythm by affecting the melatonin receptors present in the suprachiasmatic nucleus
(SCN; the master clock) of the hypothalamus.
Kava Root Extract: Nature’s Calming Companion
What is kava? How does kava work in the body?7
Kava, derived from the root of the Piper methysticum plant, has been used for centuries in traditional medicine for
its calming properties. Kava contains compounds known as kavalactones, which interact with neurotransmitters
in the brain, in particular GABA. These kavalactones exert an anxiolytic activity and can modulate GABA receptors
to induce calming effects on the nervous system, promoting relaxation without sedation.8
Through the synergy of these two ingredients in a single supplement, your patients can experience restful
nights, allowing them to wake up each morning feeling refreshed and revitalized.
Who can benefit from MetaSleep?
Patients suffering from delayed sleep phase disorder who may fall asleep slowly
Patients with a disrupted circadian rhythm (trouble falling asleep and/or staying asleep)
Patients suffering from sleep restriction or altered sleep schedule (shift-workers or those with jet lag)
Supplement Information:
- Serving Size: 1 Capsule
- Servings Per Container: 60
- Each capsule contains:
- Melatonin 1.5 mg
- Kava (Piper methysticum) root extract 300 mg (standardized to 30mg of kavalactones†)
- Non-Medicinal Ingredients: Cellulose, capsule (hypromellose, and sodium copper chlorophyllin), silica, and magnesium stearate (veg).
Recommended Use:
- Helps increase the total sleep time in individuals with sleep restriction or altered sleep schedules.
- Helps reduce the time it takes to fall asleep in people experiencing difficulty falling asleep or with delayed sleep phase disorder.
Recommended Dose:
- Adults: Take 1 capsule per day at or before bedtime or as directed by your healthcare practitioner.
- Jet Lag Use: Take 1 capsule once daily at bedtime while traveling, and at destination until adapted to the new time zone or daily pattern.
Caution:
- Do not use if you have liver or kidney disorders, or if you are pregnant or breastfeeding.
- Avoid driving or operating heavy machinery for 5 hours after taking melatonin.
- Consult a healthcare practitioner prior to use if you suffer from epilepsy, or have cardiovascular, immune, hormonal, or seizure disorders, asthma, depression, diabetes, low blood sugar, or migraine.
- Consult a healthcare practitioner prior to use if you are taking medications for seizure, blood pressure, immune suppression, mental state alteration, sedation, steroids, blood thinners, sedative hypnotics, antipsychotics, MAO inhibitors, psycho-pharmacological agents, levodopa (or other drugs for Parkinson’s disease), or antithrombotics.
- Discontinue use and consult a healthcare practitioner if you experience allergy symptoms, headache, confusion, nausea, symptoms of liver trouble (yellowing of the skin/eyes, stomach pain, dark urine, sweating, unusual tiredness, loss of appetite), or hypersensitivity reactions.
- Avoid consumption with alcohol, sedatives, anti-convulsants, or products causing drowsiness.
- Consult a healthcare practitioner for use beyond 4 weeks, if sleeplessness persists continuously for more than 4 weeks, or if symptoms persist or worsen.
Additional Information:
- Gluten-free
- Non-GMO
- Vegetarian
Bookan appointment with one of our Naturopathic Doctors or consult with a qualified healthcare practitioner.
References:
1. Gamble KL et al. Circadian clock control of endocrine factors. Nat Rev Endocrinol. 2014;10(8):466-475.
2. Healy KL et al. Circadian synchrony: sleep, nutrition, and physical activity. Front Nets Physiol.
2021;1:732243.
3. Medic G et al. Short and long-term health consequences of sleep disruption. Nat Sci Sleep.
2017;9:151-161.
4. Sejbuk M et al. Sleep quality: a narrative review on nutrition, stimulants, and physical activity as
important factors. Nutrients. 2022;14(9):1912.
5. Zhao M et al. The effects of dietary nutrition on sleep and sleep disorders. Mediators Inflamm.
2020;2020:3142874.
6. Srinivasan V et al. Melatonin and melatonergic drugs on sleep: possible mechanisms of action.
Int J Neurosci. 2009;119(6):821-846.
7. Bian T et al. Kava as a clinical nutrient: promises and challenges. Nutrients. 2020;12(10):3044.
8. Savage KM et al. Kava for the treatment of generalised anxiety disorder (K-GAD): study protocol for a
randomised controlled trial. Trials. 2015;16:493.
